Efficient control of transient wave forms to prevent spreading depolarizations
نویسندگان
چکیده
منابع مشابه
Efficient control of transient wave forms to prevent spreading depolarizations.
In various neurological disorders spatio-temporal excitation patterns constitute examples of excitable behavior emerging from pathological pathways. During migraine, seizure, and stroke an initially localized pathological state can temporarily spread indicating a transition from non-excitable to excitable behavior. We investigate these transient wave forms in the generic FitzHugh-Nagumo (FHN) s...
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Spreading depression (SD) is a transient wave of near-complete neuronal and glial depolarization associated with massive transmembrane ionic and water shifts. It is evolutionarily conserved in the central nervous systems of a wide variety of species from locust to human. The depolarization spreads slowly at a rate of only millimeters per minute by way of grey matter contiguity, irrespective of ...
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UNLABELLED Spreading depolarizations (SDs) are recognized as actors in neurological disorders as diverse as migraine and traumatic brain injury (TBI). Migraine aura involves sensory percepts, suggesting that sensory cortices might be intrinsically susceptible to SDs. We used optical imaging, MRI, and field potential and potassium electrode recordings in mice and electrocorticographic recordings...
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Spreading depolarizations (SDs) are coordinated depolarizations of brain tissue that have been well-characterized in animal models and more recently implicated in the progression of stroke injury. We previously showed that extracellular Zn(2+) accumulation can inhibit the propagation of SD events. In that prior work, Zn(2+) was tested in normoxic conditions, where SD was generated by localized ...
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ژورنال
عنوان ژورنال: Journal of Theoretical Biology
سال: 2008
ISSN: 0022-5193
DOI: 10.1016/j.jtbi.2007.11.019